Candida Chorioamnionitis Leads to Preterm Birth and Adverse Fetal-Neonatal Outcome

Table 1

Clinical features of nine cases of Candida chorioamnionitis in our hospital.

Case	Age (y)	GA at delivery	Species	Positive culture	Predisposing conditions	Clinical signs	BW (g)	CCC	Neonatal outcome
1	31	21 w 6 d	Candida albicans	Amniotic fluid	IVF	Preterm labor and afebrile; WBC: 16,500/mm^3; CRP: 0.51 mg/dL	490	No	Artificial abortion
2	31	22 w 6 d	C. glabrata	Amniotic fluid	IVF	Preterm labor and afebrile; WBC: 11,600/mm^3; CRP: 1.68 mg/dL	594	Yes	Death on day 59
3	28	23 w 0 d	C. famata	Amniotic fluid	Smoking	Preterm labor and afebrile; WBC: 16,400/mm^3; CRP: 0.68 mg/dL	498	No	Hydrocephalus after IVH
4	35	23 w 3 d	C. albicans	Amniotic fluid	IVF; Gestational diabetes	Preterm labor and afebrile; WBC: 11,700/mm^3; CRP: 3.71 mg/dL	580	Yes	Neonatal death
5	28	23 w 4 d	C. albicans	Amniotic fluid	Pregestational diabetes	Preterm labor and afebrile; WBC: 12,600/mm^3; CRP: 3.8 mg/dL	536	No	Brain atrophy and CLD
6	33	25 w 2 d	C. albicans	Amniotic fluid	None	Preterm labor and afebrile; WBC: 15,400/mm^3; CRP: 7.51 mg/dL	786	No	PDA ligation
7	26	26 w 6 d	C. albicans	Amniotic fluid	None	Preterm labor and afebrile; WBC: 9,800/mm^3; CRP: 3.05 mg/dL	924	Yes	CLD
8	36	28 w 2 d	C. albicans	Umbilical blood	Di-Di twins	Preterm labor and afebrile; WBC: 9,500/mm^3; CRP: 3.34 mg/dL	1,290/1,168	No	Normal; Only one twin had; the infection
9	38	33 w 3 d	C. glabrata	Amniotic fluid	pPROM	Afebrile,; WBC: 10,200/mm^3; CRP: 2.68 mg/dL	1,912	No	Normal

GA, gestational age; BW, birth weight; CCC, congenital cutaneous candidiasis; IVF, in vitro fertilization; Di-Di twin, dichorionic diamniotic twin; WBC, white blood cell; CRP, C-reactive protein; IVH, intraventricular hemorrhage; CLD, chronic lung disease; PDA, patent ductus arteriosus; pPROM, preterm premature rupture of membranes.