Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study
Table 1
Demographic and clinical characteristics by GBS status.
GBS Negative
GBS Colonized
Invasive GBS
P Value1
P Value2
(N=47,013)
(N=12,952)
(N=64)
Age at delivery (years)
Mean (SD)
28.7 (6.2)
28.0 (6.2)
28.1 (6.4)
<.001
0.95
Race, n ()
Black or African American
14012/44293 (31.6%)
5660/12379 (45.7%)
39/64 (60.9%)
<.001
0.05
White or Caucasian
20325/44293 (45.9%)
4740/12379 (38.3%)
19/64 (29.7%)
-
-
Other
9956/44293 (22.5%)
1979/12379 (16.0%)
6/64 (9.4%)
-
-
Ethnicity, n ()
Hispanic
7506/44657 (16.8%)
1467/12443 (11.8%)
2/63 (3.2%)
<.001
0.08
Not Hispanic
35580/44657 (79.7%)
10611/12443 (85.3%)
58/63 (92.1%)
-
-
Other
1571/44657 (3.5%)
365/1244 (2.9%)
3/63 (4.8%)
-
-
Antibiotic use
Inpatient antibiotic administered
1590/47013, 3.4%
1271/12952, 9.8%
3/64, 4.7%
<0.001
0.17
during pregnancy prior to delivery
Risk factors, n ()
Chronic hypertension
3366/47013 (7.2%)
1112/12952 (8.6%)
16/64 (25.0%)
<0.001
<.001
Pre-existing diabetes
1294/47013 (2.8%)
456/12952 (3.5%)
10/64 (15.6%)
<0.001
<.001
Autoimmune disorder
310/47013 (0.7%)
72/12952 (0.6%)
0/64 (0%)
0.19
1.00
Chronic infectious disease3
368/47013 (0.8%)
106/12952 (0.8%)
1/64 (1.6%)
0.69
0.41
Tobacco use
5887/33129 (17.8%)
2010/9674 (20.8%)
14/51 (27.5%)
<0.001
0.23
1P value for comparison of GBS negative versus GBS colonized. 2P value for comparison of GBS colonized versus invasive GBS. 3Human immunodeficiency virus, hepatitis B, and hepatitis C. P value from t-test or Chi-square or Fisher’s exact test.
