| | First author | Organ (or tissue) of interest | Radiation type and dose | SeNPs dose/concentration | Time for outcome assessment | Main outcomes |
| | Yazdi et al. [28] | Blood, heart, brain, liver, spleen, and lung | X-ray, 2, 4, and 8 Gy, whole body irradiation | 100 μg/day, oral 30 days | 10, 20, and 30 days | 1. SeNPs help to restore bone marrow function and significantly increase the numbers of lymphocytes and neutrophils in mice that have suffered from bone marrow suppression in irradiated mice
2. Deposition of SeNPs in the liver
3. Better recovery, especially in groups exposed to radiation with doses of 2 and 4 Gy | | Fahmy et al. [29] | Blood, liver tissue (renin, IL6, PON-1, and GPx activity) | γ-Ray, 0.7 Gy, whole body irradiation | 0.5 mg/kg, oral | 24 hr | 1. A combination of SeNPs and fish oil has the potential to mitigate the harm the liver caused by exposure to IR and cisplatin | | Zahran et al. [30] | Blood and kidney tissue | γ-Ray, 0.5 Gy, whole body irradiation | 0.1 mg/kg, oral | 24 hr | SeNPs effectively prevent kidney damage and have the ability to scavenge free radicals and protect against nicotine toxicity by reducing inflammation through antioxidant activity | | El-Ghazaly et al. [31] | Paw edema | γ-Ray, 6 Gy | 2.55 mg/kg, oral | 24 hr | 1. Nano-Se was able to reduce paw edema in inflamed and irradiated rats by 35% and 47%, respectively
2. Anti-inflammatory activity may occur through the downregulation of pro-inflammatory genes and/or in addition to their antioxidant activity | | Karami et al. [26] | Blood and kidney tissue | γ-Ray, 2 and 8 Gy | 0.5 mg/kg, IP | 48 hr | SeNPs, which are a newly recognized powerful antioxidant agent, have the ability to protect against nephropathy caused by IR exposure | | Saif-Elnasr et al. [32] | Blood and kidney tissue | γ-Ray, 0.7 Gy | 0.5 mg/kg, oral/12 day | 24 hr | Pretreatment with fish oil and/or SeNPs:
1. Prevention of kidney damage caused by cisplatin and radiation
2. Reduced CP and γ-radiation-induced high levels in renal Casp-3 and COX-2 activities
3. Ameliorated the renal levels of trace elements, urea, creatinine, and TNF-a
4. Increased renal TAC levels | | Sohrabi et al. [33] | Blood and liver tissue | γ-Ray, 2 and 8 Gy | 0.10 mg/kg, IP | 72 hr | 1. Decreased liver damage, antioxidant effect
2. Reducing the response recorded in enzyme activity of AST, ALT, ALP, and GGT | | Jafarpour et al. [34] | Lymphocyte | γ-Ray, 20 µCi
40 mGy | 0.025 mg/mL | 2 hr | The levels of DSBs caused by IR in peripheral lymphocytes decreased by utilizing melatonin and SeNPs | | Hasanzadeh et al. [35] | CHO cells | X-ray, 0.5, 1, and 2 Gy | 0.21625, 0.4325, 0.865, 1.73 ppm | 24 hr | The process of creating selenium nanoparticles in rosemary extract did not have a combined protective effect against IR on CHO cells | | Ehghaghi et al. [36] | Testis | X-ray, 2 Gy | 0.2 mg/kg, oral | NI, not informed | SeNPs and probiotics reduce testicular damage and improve antioxidant status in male mice |
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