Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent

Table 4

Influence of small variations in the assay conditions on the analytical performance of the proposed spectrophotometric method for determination of PRX using NQS reagent.

Parameters	Recovery (%  ± SD)(a)
Recommended conditions(b)	100.5±1.35
NQS concentration (%, w/v)
0.25	98.8±0.85
0.75	100.4±1.25
Buffer solution (pH)
8.8	98.9±1.87
9.2	101.5±1.67
Reaction time (min)
5	99.5±1.87
15	100.2±0.85

(a)Values are mean of 3 determinations.
(b)The recommended conditions are given in Section 2.