Kinetic Spectrophotometric Determination of Certain Cephalosporins in Pharmaceutical Formulations

Table 7

Determination of studied drugs in their pharmaceutical dosage forms using initial rate and fixed time methods.

Drug	Pharmaceutical dosage form	Proposed methods ± SD (𝑛 = 5)		Reported methods ± SD
		Initial rate	Fixed time	(𝑛 = 5)
Cefotaxime	Cefotax vials	100.67 ± 0.9359	99.98 ± 1.146	100.58 ± 0.9753
		𝑡=0.1423^∗	𝑡=0.8914
		𝐹=1.086^∗	𝐹=1.382
Cephapirin	Cefatrexyl vials	100.57 ± 0.9274	99.87 ± 1.112	100.17 ± 1.208
		𝑡=0.5901	𝑡=0.4193
		𝐹=1.698	𝐹=1.180
Cephradine	Velosef suspension	99.85 ± 1.274	99.4 ± 1.699	99.89 ± 1.190
		𝑡=0.1227	𝑡=0.5303
		𝐹=1.346	𝐹=2.039
Cephradine	Velosef capsuls	100.1 ± 1.071	100.56±0.6226	100.25 ± 0.7994
		𝑡=0.2477	𝑡=0.6753
		𝐹=1.793	𝐹=1.649
Cephalexin	Ceporex vials	99.69 ± 1.0	100.43 ± 0.918	100.19 ± 0.9310
		𝑡=0.8248	𝑡=0.4069
		𝐹=1.154	𝐹=1.027
Cephalexin	Ceporex tablets	99.93 ± 1.370	100.06 ± 1.647	99.98 ±1.112
		𝑡=0.06844	𝑡=0.08551
		𝐹=1.518	𝐹=2.194
Ceftazidime	Fortum vials	99.2 ± 1.261	99.74 ± 1.212	99.78 ± 0.6750
		𝑡=0.9192	𝑡=0.7738
		𝐹=3.490	𝐹=3.222
Cefazoline	Totacef vials	99.69 ± 1.586	99.35 ± 1.059	99.25 ± 1.379
		𝑡=0.4724	𝑡=0.1234
		𝐹=1.321	𝐹=1.695
Ceftriaxone	Ceftriaxone vials	99.92 ± 1.292	99.43 ± 1.185	100.04 ±0.9742
		𝑡=0.1658	𝑡=0.8951
		𝐹=1.760	𝐹=1.479
Cefuroxime	Zinnat vials	100.31 ± 1.091	99.82 ± 1.105	100.33 ± 0.7431
		𝑡=0.0373	𝑡=0.8533
		𝐹=2.157	𝐹=2.209

∗Tabulated value at 95% confidence limit; 𝑡=2.306 and 𝐹=6.388.