A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance
Figure 3
Aromatic region of the
NMR spectra of the enriched impurity fraction ((a) 600 MHz) and AMG 517 ((b)
400 MHz) in DMSO-d6. In (a), numbers designated as prime (e.g., )
represent signals of Unknown 1, with all others representing signals of Unknown
2.
