A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance
Table 5
Mass
error analysis of the observed accurate mass for fragments generated by the
acid hydrolysis of the enriched impurity fraction. The analysis is conducted
for both the thioether and bis-sulfoxide structures proposed for Unknown 2.
(ND: not detected; N/A: not applicable.)