Titrimetric and Spectrophotometric Assay of Oxcarbazepine in Pharmaceuticals Using N-Bromosuccinimide and Bromopyrogallol Red
Table 3
Robustness and ruggedness.
Method A
Method B
OXC studied mg
Robustness (RSD, %)
Ruggedness (RSD, %)
OXC studied μg mL−1
Robustness (RSD, %)
Ruggedness (RSD, %)
Conditions altered*
Inter-analysts (n = 4)
Inter-instruments (n = 3)
Volume of H2SO4 (n = 3)
Inter-analysis (n = 4)
Inter-burettes (n = 4)
Volume of BPR (n = 3)
Reaction time (n = 3)
6.0
3.10
2.22
2.89
2.0
3.15
1.52
2.21
1.89
12.0
2.69
1.89
2.65
4.0
3.02
2.56
1.89
1.56
18.0
2.50
1.56
2.56
6.0
2.10
1.26
2.00
2.13
*In method A, volumes of 10 M H2SO4 varied were 10 ± 1 mL, In method B, volumes of BPR varied were 1 ± 0.1 mL, and the reaction time employed was 30 ± 2 min.
