Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations

Table 2

Sensitivity and regression parameters.

Parameter	Method C	Method D
max,λ nm	610	530
Linear range, 𝜇g mL^−1	0.75–6.0	0.3–3.0
Molar absorptivity(𝜀), L mol^−1 cm^−1	4.199×10^4	1.089×10^5
Sandell sensitivitya, 𝜇g cm^-2	0.008	0.003
Limit of detection (LOD), 𝜇g mL^−1	0.05	0.02
Limit of quantification (LOQ), 𝜇g mL^−1	0.16	0.06
Regression equation, Yb
Intercept (𝑎)	0.011	0.02
Slope (𝑏)	0.122	0.303
Standard deviation of a (𝑆𝑎)	0.048	0.063
Standard deviation of b (𝑆𝑏)	0.009	0.023
Regression coefficient (𝑟)	0.996	0.999

aLimit of determination as the weight in 𝜇g per mL of solution, which corresponds to an absorbance of A=0.001 measured in a cuvette of cross-sectional area 1 cm² and l=1cm. ^b𝑌=𝑎+𝑏𝑋, where 𝑌 is the absorbance, 𝑋 is concentration in 𝜇g mL⁻¹, 𝑎 is intercept, and 𝑏 is slope.