Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations
Table 2
Sensitivity and regression parameters.
Parameter
Method C
Method D
,λ nm
610
530
Linear range, g mL−1
0.75–6.0
0.3–3.0
Molar absorptivity(), L mol−1 cm−1
Sandell sensitivity, g cm-2
0.008
0.003
Limit of detection (LOD), g mL−1
0.05
0.02
Limit of quantification (LOQ), g mL−1
0.16
0.06
Regression equation, Y
Intercept ()
0.011
0.02
Slope ()
0.122
0.303
Standard deviation of a ()
0.048
0.063
Standard deviation of b ()
0.009
0.023
Regression coefficient ()
0.996
0.999
Limit of determination as the weight in g per mL of solution, which corresponds to an absorbance of measured in a cuvette of cross-sectional area 1 cm2 and . , where is the absorbance, is concentration in g mL−1, is intercept, and is slope.