Research Article

Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations

Table 5

Results of analysis of tablets by the proposed methods.

Tablet brand nameLabel claim,  mg/tabletFound (percent of label claim ± SD)
Reference methodTitrimetrySpectrophotometry
Method AMethod BMethod CMethod D

Topcid 20 20102.5 ± 0.93101.21 ± 1.19
t = 1.92
F = 1.63
101.24 ± 0.87
t = 2.21
F = 1.14
103.5 ± 0.91
t = 1.72
F = 1.04
103.7 ± 1.07
t =1.90
F = 1.32
Famocid 20 20101.3 ± 1.0299.56 ± 1.17
t = 2.51
F = 0.76
99.86 ± 1.06
t = 2.19
F = 0.93
102.7 ± 1.09
t =2.09
F =1.11
102.5 ± 0.95
t = 1.92
F = 0.98

Mean value of five determinations. Torrent Pharmaceuticals Ltd., H. P, India; Sun Pharmaceuticals Industries, Jammu, India.
The value of t (tabulated) at 95% confidence level and for four degrees of freedom is 2.77.
The value of F (tabulated) at 95% confidence level and for four degrees of freedom is 6.39.