Sensitive and Selective Spectrophotometric Determination of Gabapentin in Capsules Using Two Nitrophenols as Chromogenic Agents

Table 1

Chromatographic methods reported for the determination of GBP in pharmaceuticals.

Technique	Chromatographic conditions			LOD, mg mL^−1	Range, μg mL^−1	Ref.
	Mobile phase	Flow rate, mL min^−1	Detection, UV, nm
(1) HPLC	Ammonium dihydrogen orthophosphate buffer and methanol in 60 : 40 (v/v)	1.0	200	NR	2500–7500	[6]
(2) HPLC	Methanol-acetonitrile- potassium dihydrogen phosphate (pH 5.2; 0.028 M) (25 : 10 : 65, v/v)	1.0	210	NR	100–3800	[7]
(3) HPLC	Acetonitrile-sodium dihydrogenphosphate (pH 2.5; 0.05 M) (70 : 30, v/v)	1.5	360	NR	10–500	[8]
(4) HPLC	Methanol-potassium dihydrogen orthophosphate solution (20 : 80, v/v) containing 10% NaOH	1.0	275	NR	940–1060	[9]
(5) HPLC	Acetonitrile-10 mM KH2PO4/10 mM K2HPO4 (pH 6.2) (8 : 92, v/v)	1.0	210	0.005	500–5000	[10]
(6) HPLC	Methanol-acetonitrile-20 mM KH2PO4 (pH 2.2) (5 : 5 : 90, v/v/v)	1.25	210	0.015	50–650	[11]

NR: Not reported.