Quantification of Lansoprazole in Oral Suspension by Ultra-High-Performance Liquid Chromatography Hybrid Ion-Trap Time-of-Flight Mass Spectrometry

Table 1

Intraday precision (% relative standard deviation (% RSD)) and accuracy (% error) of the LC-MS/MS assay for quantification of lansoprazole (n = 5 for each concentration for each day).

Concentration of lansoprazole added (μg/mL)	Concentration of lansoprazole found (μg/mL)	% Relative standard deviation	% Error
Day 1
5	5.17 ± 0.15	2.90	2.81
10	10.28 ± 0.12	1.16	2.81
15	15.04 ± 0.65	4.35	0.30
20	20.83 ± 0.27	1.28	4.17
25	24.76 ± 0.72	2.91	0.96
Day 2
5	5.12 ± 0.54	10.54	2.06
10	10.31 ± 0.18	1.79	3.07
15	15.15 ± 0.63	4.13	1.02
20	21.04 ± 0.46	2.18	5.22
25	25.04 ± 0.73	2.90	0.15
Day 3
5	4.95 ± 0.15	3.03	0.81
10	9.90 ± 0.11	1.16	0.98
15	14.48 ± 0.63	4.34	3.47
20	20.04 ± 0.26	1.28	0.21
25	23.82 ± 0.69	2.90	4.74
Day 4
5	5.04 ± 0.15	2.98	0.65
10	10.05 ± 0.12	1.16	0.46
15	14.69 ± 0.64	4.34	2.08
20	20.33 ± 0.26	1.28	1.64
25	24.15 ± 0.70	2.90	3.38