Analysis of Digoxin and Metildigoxin in Whole Blood Using Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry

Figure 3

MRM chromatograms of whole blood samples spiked with 1 ng/mL of digoxin [(a) and (b)] and metildigoxin [(d) and (e)]; and with 5 ng/mL of d₃-digoxin, internal standard (c).

(a)

(b)

(c)

(d)

(e)