Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitation of Cremophor EL and Its Applications
Figure 6
MRM LC-MS/MS chromatograms of (a) PPG in blank rat plasma; (b) CrEL-PEG in rat blank plasma; (c) PPG spiked at 10 μg/mL concentration in rat plasma; (d) Rat plasma sample spiked with 1.00 μg/mL of CrEL-PEG; (e) plasma sample obtained 0.50 hr after intravenous administration of CrEL to SD rats; (f) plasma sample obtained 0.50 hr after oral administration of CrEL to SD rats.