Research Article
Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitation of Cremophor EL and Its Applications
Table 1
Calculated concentrations and statistical parameters of CrEL-PEG calibration standards prepared in rat plasma (
).
| Concentration (µg/mL) | Statistical parameters | Actual conc. | Calculated conc. | Mean | SD | CV% | Relative error (%) | Set 1 | Set 2 | Set 3 |
| 1.00 | 1.07 | 1.04 | 1.05 | 1.05 | 0.02 | 1.45 | 5.33 | 1.50 | 1.40 | 1.41 | 1.41 | 1.41 | 0.01 | 0.41 | −6.22 | 5.00 | 4.56 | 5.15 | 4.95 | 4.89 | 0.30 | 6.14 | −2.27 | 20.00 | 18.84 | 19.05 | 18.54 | 18.81 | 0.26 | 1.36 | −5.95 | 70.00 | 70.19 | 67.98 | 68.39 | 68.85 | 1.18 | 1.71 | −1.64 | 120.00 | 122.31 | 122.36 | 127.58 | 124.08 | 3.03 | 2.44 | 3.40 | 160.00 | 173.41 | 176.10 | 152.36 | 167.29 | 13.00 | 7.77 | 4.56 | 180.00 | 187.32 | 174.58 | 194.31 | 185.40 | 10.00 | 5.40 | 3.00 | 200.00 | 199.88 | 196.18 | 205.05 | 200.37 | 4.46 | 2.22 | 0.19 |
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