Research Article
Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitation of Cremophor EL and Its Applications
Table 3
Summary of validation parameters for CrEL-PEG in rat plasma.
| | Validation parameter | Statistical parameter | Result |
| | Extraction recovery | Mean | 103.23 | | SD | 5.28 | | CV% | 5.11 |
| | Matrix factor (matrix effect) | Mean | 1.05 | | SD | 0.03 | | CV% | 2.87 |
| | Autosampler stability | Mean | 101.04 | | SD | 3.71 | | CV% | 3.68 |
| | Bench top stability | Mean | 103.05 | | SD | 2.07 | | CV% | 2.00 |
| | Freeze thaw stability | Mean | 100.73 | | SD | 4.55 | | CV% | 4.52 |
| | Long-term stability | Mean | 104.65 | | SD | 2.89 | | CV% | 2.76 |
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