Table 4: Pharmacokinetic parameters of CrEL-PEG after intravenous administration at 0.018 g/kg dose (PEG Oligomers) in male Sprague Dawley rats.

SubjectKel
(1/hr)
(hr) (μg/mL) AUClast (hr*μg/mL) AUCINF_obs (hr*μg/mL) AUC_%Extrap_obs (%) Vz_obs (L/kg) Cl_obs (mL/min/kg) MRTlast
(hr)

RAT-10.116.29834.531714.611849.947.320.130.244.32
RAT-20.088.17745.121566.771794.6312.700.170.245.43
RAT-30.088.50609.021620.791886.8014.100.170.236.01
Mean0.097.65729.561634.061843.7911.370.160.245.25
SD0.021.19113.5674.8146.393.580.020.010.86
CV%17.0315.6015.564.582.5231.4915.732.5316.33