Research Article
Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitation of Cremophor EL and Its Applications
Table 4
Pharmacokinetic parameters of CrEL-PEG after intravenous administration at 0.018 g/kg dose (PEG Oligomers) in male Sprague Dawley rats.
| Subject | Kel (1/hr) | (hr) | (μg/mL) |
AUClast (hr*μg/mL) |
AUCINF_obs (hr*μg/mL) |
AUC_%Extrap_obs (%) |
Vz_obs (L/kg) |
Cl_obs (mL/min/kg) | MRTlast (hr) |
| RAT-1 | 0.11 | 6.29 | 834.53 | 1714.61 | 1849.94 | 7.32 | 0.13 | 0.24 | 4.32 | RAT-2 | 0.08 | 8.17 | 745.12 | 1566.77 | 1794.63 | 12.70 | 0.17 | 0.24 | 5.43 | RAT-3 | 0.08 | 8.50 | 609.02 | 1620.79 | 1886.80 | 14.10 | 0.17 | 0.23 | 6.01 | Mean | 0.09 | 7.65 | 729.56 | 1634.06 | 1843.79 | 11.37 | 0.16 | 0.24 | 5.25 | SD | 0.02 | 1.19 | 113.56 | 74.81 | 46.39 | 3.58 | 0.02 | 0.01 | 0.86 | CV% | 17.03 | 15.60 | 15.56 | 4.58 | 2.52 | 31.49 | 15.73 | 2.53 | 16.33 |
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