Research Article
Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitation of Cremophor EL and Its Applications
Table 5
Pharmacokinetic parameters of CrEL-PEG after oral administration at 0.018 g/kg dose (PEG component) in male Sprague Dawley rats.
| Subject | Kel (1/hr) | (hr) | (hr) | (μg/mL) |
AUClast (hr*μg/mL) |
AUCINF_obs (hr*μg/mL) | AUC_%Extrap_ obs (%) |
Vz_F_obs (L/kg) |
Cl_F_obs (mL/min/kg) | MRTlast (hr) | (%) |
| RAT-1 | 0.61 | 1.14 | 0.50 | 18.42 | 45.01 | 49.82 | 9.67 | 0.86 | 8.78 | 1.62 | 2.62 | RAT-2 | 0.85 | 0.82 | 0.50 | 30.50 | 46.85 | 49.07 | 4.52 | 0.63 | 8.92 | 1.31 | 2.99 | RAT-3 | 0.38 | 1.84 | 0.50 | 24.45 | 45.29 | 48.21 | 6.04 | 1.44 | 9.08 | 1.93 | 2.79 | Mean | 0.61 | 1.26 | 0.50 | 24.46 | 45.72 | 49.03 | 6.74 | 0.98 | 8.92 | 1.62 | 2.80 | SD | 0.23 | 0.52 | 0.00 | 6.04 | 0.99 | 0.81 | 2.64 | 0.42 | 0.15 | 0.31 | 0.18 | CV% | 38.39 | 41.22 | 0.00 | 24.70 | 2.17 | 1.65 | 39.20 | 42.66 | 1.65 | 19.18 | 6.52 |
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