Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitation of Cremophor EL and Its Applications

Table 5

Pharmacokinetic parameters of CrEL-PEG after oral administration at 0.018 g/kg dose (PEG component) in male Sprague Dawley rats.

Subject	Kel; (1/hr)	𝑇1/2; (hr)	𝑇max; (hr)	𝐶max; (μg/mL)	AUClast (hr*μg/mL)	AUCINF_obs (hr*μg/mL)	AUC_%Extrap_; obs (%)	Vz_F_obs (L/kg)	Cl_F_obs (mL/min/kg)	MRTlast; (hr)	𝐹 (%)
RAT-1	0.61	1.14	0.50	18.42	45.01	49.82	9.67	0.86	8.78	1.62	2.62
RAT-2	0.85	0.82	0.50	30.50	46.85	49.07	4.52	0.63	8.92	1.31	2.99
RAT-3	0.38	1.84	0.50	24.45	45.29	48.21	6.04	1.44	9.08	1.93	2.79
Mean	0.61	1.26	0.50	24.46	45.72	49.03	6.74	0.98	8.92	1.62	2.80
SD	0.23	0.52	0.00	6.04	0.99	0.81	2.64	0.42	0.15	0.31	0.18
CV%	38.39	41.22	0.00	24.70	2.17	1.65	39.20	42.66	1.65	19.18	6.52