Table 5: Pharmacokinetic parameters of CrEL-PEG after oral administration at 0.018 g/kg dose (PEG component) in male Sprague Dawley rats.

SubjectKel
(1/hr)

(hr)

(hr)

(μg/mL)
AUClast (hr*μg/mL) AUCINF_obs (hr*μg/mL) AUC_%Extrap_
obs (%)
Vz_F_obs (L/kg) Cl_F_obs (mL/min/kg) MRTlast
(hr)
(%)

RAT-10.611.140.5018.4245.0149.829.670.868.781.622.62
RAT-20.850.820.5030.5046.8549.074.520.638.921.312.99
RAT-30.381.840.5024.4545.2948.216.041.449.081.932.79
Mean0.611.260.5024.4645.7249.036.740.988.921.622.80
SD0.230.520.006.040.990.812.640.420.150.310.18
CV%38.3941.220.0024.702.171.6539.2042.661.6519.186.52