Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets

Table 4

Robustness and ruggedness.

Method A			Method B				Method C
STS studied mg	Robustness (RSD, %); Volume of HCl^a (𝑛=3)	Ruggedness (RSD, %); Interburettes (𝑛=4)	STS studied µg mL^−1	Robustness (RSD, %); Conditions altered		Ruggedness (RSD, %)	STS studied; µg mL^−1	Robustness (RSD, %); Conditions altered		Ruggedness (RSD, %)
				Volume of HCl^a; (𝑛=3)	Reaction time^b (𝑛=3)	Intercuvettes; (𝑛=3)		Volume of HCl^a; (𝑛=3)	Reaction time^b; (𝑛=3)	Intercuvettes; (𝑛=3)
4.00	0.77	1.15	6.00	1.70	1.95	2.27	1.00	1.39	1.51	1.93
6.00	1.01	0.89	9.00	2.12	1.72	2.15	2.00	1.86	1.83	2.08
8.00	0.93	1.00	12.0	1.37	1.44	1.97	3.00	1.40	1.28	1.89

aIn method A, volumes of 2 M HCl varied were 5 ± 1 mL; in both methods B and C, 2 M HCl (1 mL ± 0.1 mL).
^bIn both methods B and C, the reaction time employed was 15 ± 1 min.