Research Article
Development and Validation of Simple RP-HPLC Method for Intracellular Determination of Fluconazole Concentration and Its Application to the Study of Candida albicans Azole Resistance
Table 3
MIC values (μg/mL) for antifungal drugs FLC, VRC, and AmB of C. albicans initial andazole-resistantstrains, cultivated for 20 generations in the presence of FLC.
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The MIC was considered to be the concentration of drug that inhibited 100% of fungal growth. The fungal strains were propagated in the presence or absence of 1/25 of MIC concentration of FLC for a total of 20 generations and MIC value for FLC and VRC of each strain. |