Determination of Glucocorticoids in UPLC-MS in Environmental Samples from an Occupational Setting

Table 2

Results of environmental and personal monitoring of glucocorticoids in a pharmaceutical plant (2013).

Compound	Door handles^a			Door stops^a			Air samples^b			Hand washing^a
	()			()			()			()
	Min	Max	Mean; Std]	Min	Max	Mean; Std]	Min	Max	Mean; Std]	Min	Max	Mean; Std]
Beclomethasone dipropionate	99.8	413.3	252.7; 145.1]	193.3	3368.1	910.0; 1377.7]	1.8	388.2	87.2; 168.4]	26.8	833.8	258.4; 328.8]
Betamethasone dipropionate	17.8	89.9	48.9; 26.8]	23.8	168.0	90.8; 56.9]	<0.1	<0.1	<0.1; —]	4.0	13.0	7.9; 3.5]
Clobetasol 17-propionate	54.3	104.2	69.0; 29.2]	21.7	481.0	160.2; 186.0]	<0.1	0.9	0.2; 0.4]	11.8	33.0	19.8; 8.2]
Clocortolone pivalate	1.9	30.4	12.1; 11.2]	1.7	77.7	26.4; 30.8]	<0.1	<0.1	<0.1; —]	8.0	8.0	8.0; —]
Chlormadinone acetate	8.0	64.8	32.0; 21.9]	8.9	1219.6	298.0; 21.9]	<0.1	1.3	0.4; 0.5]	5.4	126.0	66.4; 54.4]
Delmadinone acetate	<0.1	2.0	0.4; 0.9]	<0.1	37.6	8.0; 16.5]	<0.1	<0.1	<0.1; —]	10.0	10.0	10.0; —]
Desonide	3.8	43.6	16.3; 15.8]	4.5	44.0	20.6; 15.3]	<0.1	<0.1	<0.1; —]	4.4	74.4	26.9; 29.8]
Desoximetasone	2.4	16.5	10.0; 5.5]	2.6	50.2	25.5; 19.2]	<0.1	2.0	<0.4; 0.9]	0.8	1074.3	220.2; 477.5]
Diflucortolone valerate	2.9	36.3	13.6; 13.3]	4.7	90.9	38.6; 32.3]	<0.1	<0.1	<0.1; —]	4.0	53.8	14.5; 22.0]
Exemestane	<0.1	1.3	0.4; 0.6]	<0.1	41.5	8.6; 18.4]	<0.1	<0.1	<0.1; —]	9.0	9.0	9.0; —]
Fluocinolone acetonide	6.7	52.1	23.2; 17.8]	5.3	47.5	24.1; 18.0]	<0.1	<0.1	<0.1; —]	5.0	30.0	17.0; 11.1]
Fluocinonide	17.2	73.4	42.8; 21.2]	16.5	109.4	58.9; 39.1]	<0.1	0.7	0.2; 0.3]	7.0	59.5	26.8; 21.7]
Fluprednidene acetate	5.9	35.2	13.7; 12.2]	5.3	79.6	32.2; 28.1]	<0.1	<0.1	<0.1; —]	5.0	5.4	5.1; 0.2]
Halcinonide	<0.1	0.5	0.2; 0.3]	<0.1	1.2	0.5; 0.4]	<0.1	<0.1	<0.1; —]	3.8	4.0	4.0; 0.1]
Halometasone monohydrate	1.0	7.8	4.3; 2.9]	1.0	13.1	7.1; 4.8]	<0.1	<0.1	<0.1; —]	13.0	13.0	13.0; —]
Hydrocortisone acetate	3.2	32.8	14.6; 11.9]	3.5	115.9	38.0; 46.2]	<0.1	<0.1	<0.1; —]	2.0	2.1	2.0; 0.1]
Megestrol acetate	3.1	31.5	9.5; 12.3]	5.3	86.6	26.8; 33.7]	<0.1	1.7	0.4; 0.8]	5.4	86.0	22.4; 35.6]
Methylprednisolone acetate	<0.1	1.4	0.6; 0.7]	<0.1	3.0	1.4; 1.4]	<0.1	<0.1	<0.1; —]	23.0	23.0	23.0; —]
Mometasone furoate	7.6	270.0	93.8; 109.5]	15.4	182.9	60.9; 70.4]	<0.1	58.3	12.0; 25.9]	12.0	128.8	58.6; 47.7]
Prednisolone 17-valerate 21-acetate	4.4	17.1	9.3; 5.2]	1.6	22.7	10.7; 7.7]	<0.1	21.0	4.2; 9.4]	6.0	23.9	9.6; 8.0]
Triamcinolone acetonide	10.8	63.5	30.5; 22.5]	18.8	92.1	49.9; 30.7]	<0.1	<0.1	<0.1; —]	4.9	13.1	6.8; 3.6]

Absolute µg.
^bµg/m³.