Determination of Glucocorticoids in UPLC-MS in Environmental Samples from an Occupational Setting

Table 3

Results of pad-tests on workers clothes of a pharmaceutical plant (2013). For each sample . “I” indicates the internal surface of the smocks.

Compound	Torax; Mean (Min–Max); Std]	Right forearm; Mean (Min–Max); Std]	Left forearm; Mean (Min–Max); Std]	Back; Mean (Min–Max); Std]	Right thigh; Mean (Min–Max); Std]	Left thigh; Mean (Min–Max); Std]	Right forearm - I; Mean (Min–Max); Std]	Left forearm - I; Mean (Min–Max); Std]
Beclomethasone dipropionate	661.7 (5.5–3203.4); 1421.0]	253.0 (6.1–1095.7); 472.0]	473.2 (7.8–2254.2); 995.7]	11.0 (0.7–48.8); 21.2]	294.0 (17.3–1138.0); 479.4]	298.3 (1.0–1080.2); 466.7]	9.4 (0.8–19.1); 6.66]	8.4 (3.9–14.8); 4.60]
Betamethasone dipropionate	2.4 (0–4.1); 1.9]	3.0 (0–5.1); 2.0]	3.7 (1.9–4.6); 1.1]	0.1 (0–0.4); 0.2]	4.7 (0.8–9.8); 3.3]	1.4 (0.7–2.8); 0.9]	0.4 (0–1.1); 0.4]	0.8 (0–2.2); 0.9]
Clobetasol 17-propionate	2.7 (1.4–4.0); 1.3]	4.1 (1.6–7.5); 2.4]	3.5 (1.9–6.0); 1.7]	0.3 (0–0.5); 0.3]	10.8 (3.3–31.0); 11.4]	6.3 (1.0–25.8); 10.9]	1.9 (0.5–4.9); 1.7]	1.2 (0.5–2.6); 0.9]
Clocortolone pivalate	0.1 (0–0.5); 0.2]	0.2 (0–0.5); 0.3]	0.1 (0–0.5); 0.2]	0.1 (0–0.5); 0.2]	0.4 (0–0.5); 0.2]	0.1 (0–0.5); 0.2]	0.1 (0–0.5); 0.2]	0.1 (0–0.5); 0.2]
Chlormadinone acetate	6.2 (1.5–14.9); 6.2]	5.5 (2.3–10.0); 3.2]	6.2 (1.0–16.2); 5.8]	0.7 (0–1.1); 0.5]	8.3 (2.0–18.6); 7.1]	3.8 (0.5–7.5); 2.6]	10.0 (0–25.0); 11.1]	5.8 (3.9–8.2); 2.1]
Delmadinone acetate	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]
Desonide	4.1 (0–16.6); 7.0]	5.5 (0–21.7); 9.2]	4.3 (0–14.7); 6.0]	<0.1 (—); —]	5.4 (0.8–18.9); 7.7]	2.2 (0–6.9); 2.9]	1.5 (0–3.7); 1.8]	0.8 (0–3.4); 1.5]
Desoximetasone	1.9 (0–5.1); 2.4]	2.4 (0–8.1); 3.9]	6.9 (0–26.7); 13.2]	<0.1 (—); —]	3.3 (0–10.9); 5.2]	2.6 (0–10.6); 5.3]	5.7 (0–22.8); 11.4]	3.3 (0–12.4); 6.1]
Diflucortolone valerate	0.5 (0–1.1); 0.5]	0.8 (0–1.4); 0.5]	1.2 (0–4.1); 1.7]	<0.1 (—); —]	0.9 (0–2.1); 1.0]	0.4 (0–1.9); 0.8]	3.4 (0–17.2); 7.7]	7.7 (0–30.2); 15.0]
Exemestane	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]
Fluocinolone acetonide	1.1 (0–1.9); 0.7]	2.6 (0–9.5); 3.9]	2.6 (0–10.6); 4.5]	<0.1 (—); —]	3.2 (0–10.8); 4.3]	1.6 (0–6.2); 2.7]	0.5 (0–1.7); 0.8]	0.8 (0–2.5); 1.2]
Fluocinonide	2.8 (0.5–6.3); 2.7]	7.8 (1.2–26.5); 10.6]	7.7 (0.8–30.2); 12.7]	<0.1 (—); —]	6.5 (1.4–19.0); 7.4]	3.9 (0–16.6); 7.1]	2.0 (0–6.0); 2.5]	1.5 (0–4.6); 1.9]
Fluprednidene acetate	0.3 (0–0.9); 0.4]	0.5 (0–0.8); 0.3]	0.8 (0–3.0); 1.2]	<0.1 (—); —]	0.9 (0–1.7); 0.7]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]
Halcinonide	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]
Halometasone monohydrate	1.0 (1.0–1.1); 0]	1.4 (1.0–2.8); 0.8]	1.2 (1.0–2.1); 0.5]	1.0 1.0; 0]	1.5 (1.0–3.3); 1.0]	1.0 1.0; 0]	1.0 1.0; 0]	1.0 1.0; 0]
Hydrocortisone acetate	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]	<0.1 (—); —]
Megestrol acetate	6.9 (0–34.0); 15.1]	2.1 (0–8.0); 3.4]	8.3 (0–40.0); 17.7]	0.8 (0–3.0); 1.5]	15.1 (0.5–73.0); 32.3]	1.5 (0–7.0); 3.1]	1.9 (0–8.0); 3.5]	2.1 (0–9.0); 3.9]
Methylprednisolone acetate	1.4 1.4; 0]	1.4 1.4; 0]	1.4 1.4; 0]	1.4 1.4; 0]	1.4 1.4; 0]	1.4 1.4; 0]	1.4 1.4; 0]	1.4 1.4; 0]
Mometasone furoate	129.3 (8.8–453.1); 216.4]	418.3 (2.8–1573.0); 770.9]	576.2 (7.2–2262.6); 1124.3]	10.9 (0–42.0); 20.7]	414.0 (8.7–1554.4); 760.6]	372.2 (2.0–1445.7); 715.8]	10.6 (2.0–20.8); 9.4]	9.5 (1.5–31.0); 14.4]
Prednisolone 17-valerate 21-acetate	37.9 (0–187.7); 83.8]	93.8 (0–466.8); 208.5]	44.0 (0–218.8); 97.7]	0.9 (0–4.7); 2.1]	61.9 (0–305.9); 136.4]	10.2 (0–50.3); 22.4]	1.6 (0–8.0); 3.6]	0.6 (0–3.0); 1.3]
Triamcinolone acetonide	2.5 (0–8.4); 3.6]	3.5 (0–12.6); 5.2]	2.2 (0.3–5.2); 2.0]	<0.1 (—); —]	3.4 (0–9.1); 3.7]	0.6 (0–1.8); 0.7]	0.2 (0–0.9); 0.4]	0.4 (0–1.4); 0.6]