Research Article
High Performance Liquid Chromatographic Assay for the Simultaneous Determination of Posaconazole and Vincristine in Rat Plasma
Table 1
Precision and accuracy for the determination of PSZ and VCR in rat plasma using the proposed HPLC-DAD method.
| | Nominal concentration ng/mL | Drug | Intraday mean ± SD (intraday CV%) | Interday mean ± SD, ng/mL | Interday CV% | Interday mean error% |
| | 50 | PSZ | 57.3 ± 10.5 (18.2) | 54.9 ± 9.54 (17.4) | 57.4 ± 0.86 (1.49) | 56.5 ± 0.05 | 1.36 | 13.1 | | VCR | 50.3 ± 5.99 (11.9) | 56.2 ± 2.21 (3.93) | 47.3 ± 3.07 (6.48) | 51.3 ± 4.5 | 8.78 | 2.53 |
| | 500 | PSZ | 539 ± 29.8 (5.54) | 516 ± 68.3 (13.2) | 520 ± 32.1 (6.18) | 524 ± 12.0 | 2.28 | 4.99 | | VCR | 528 ± 27.5 (5.21) | 495 ± 17.4 (3.50) | 540 ± 56.9 (10.5) | 521 ± 23.0 | 4.41 | 4.25 |
| | 2500 | PSZ | 2460 ± 383 (15.6) | 2413 ± 127 (5.25) | 2579 ± 270 (10.5) | 2483 ± 85.7 | 3.45 | −0.65 | | VCR | 2494 ± 282 (11.3) | 2646 ± 186 (7.03) | 2476 ± 264 (10.7) | 2539 ± 93.6 | 3.69 | 1.54 |
|
|
