Nanotechnology-Based Surface Plasmon Resonance Affinity Biosensors for In Vitro Diagnostics

Table 3

Main analytical performances of the reviewed biosensors based on bulk SPR.

Analytes	Nanoparticles	Biotransducer	Detection limit (LOD)	IVDD class	References
PSA	AuNPs	Antibody	0.1 ng mL^−1	C	Jung et al., 2009 [32]
Ischemia modified albumin (IMA)	AuNPs	Antibody	10 ng mL^−1	C	Li et al., 2013 [33]
Progesterone	AuNPs	Antibody	4.9 ng mL^−1	B	Yuan et al., 2007 [34]
Insulin	AuNPs	Antibody	0.5 pM	B	Frasconi et al., 2010 [36]
Dopamine	AuNPs	Antibody	2 nM	B	Matsui et al., 2005 [37]
PSA	AuNPs	Antibody	0.3 ng mL^−1	C	Uludag and Tothill, 2012 [38]
PSA	AuNPs	Antibody	300 fM	C	Choi et al., 2008 [39]
Human cardiac myoglobin (cMb)	AuNPs	Antibody	10 pM	B	Gnedenko et al., 2013 [40]
CEA	Bio-AuNPs	Antibody	0.1 ng mL^−1	C	Špringer  and Homola, 2012 [41]
CEA	AuNPs	Antibody	—	C	Špringer et al., 2014 [35]
Necrosis factor alpha (TNF-α)	Gold nanorods (GNRs)	Antibody	0.5 ng mL^−1	C	Law et al., 2011 [42]
Thrombin (Thr)	AuNPs	Aptamer	0.1 nM	B	Bai et al., 2013 [43]
Brain natriuretic peptide (BNP)	Gold nanocubes (AuNCs)	Antibody/aptamer	—	C	Jang et al., 2014 [44]
Thrombin (Thr)	Nanorods (NRs) and quasi-spherical nanoparticles (qsNPs)	Aptamer	0.1 aM	B	Baek et al., 2014 [45]
Thrombin (Thr)	AuNPs	Aptamer	0.8 aM	B	He et al., 2014 [46]
Thrombin (Thr)	Fe3O4 MNPs	Aptamer	0.02 nM	B	Wang et al., 2011 [47]
α-fetoprotein (α-FET)	Core-shell Fe3O4-Au magnetic nanoparticles (MNPs)	Antibody	0.65 ng mL^−1	C	Liang et al., 2012 [48]
Staphylococcal Enterotoxin B (SEB)	Immunomagnetic beads (IMBs)	Antibody	0.1 ng mL^−1	C	Soelberg et al., 2009 [49]