Nanotechnology-Based Surface Plasmon Resonance Affinity Biosensors for In Vitro Diagnostics

Table 4

Main analytical performances of the reviewed biosensors based on localized SPR.

Analytes	Nanoparticles	Biotransducer	Detection limit (LOD)	IVDD class	References
Amyloid-derived diffusible ligands (ADDL)	AuNPs	Antibody	—	C	Haes et al., 2005 [50]
Avian influenza (A)	AuNPs	Antibody	1 pg mL^−1	C	Park et al., 2012 [51]
HIV-1	AuNPs	Antibody	0.2 pg mL^−1	D	Lee et al., 2013 [52]
Extracellular adherence protein (EAP)/PSA	AuNPs	Antibody	8 nM/1 pM	C	Chen et al., 2009 [53]
Squamous cell carcinoma antigen (SCCa)	AuNPs	Antibody	0.125 pM	C	Zhao et al., 2014 [54]
α-fetoprotein (AFP)/PSA	AuNPs	Antibody	41 zM	C	Aćimović et al., 2014 [55]
Human epididymis secretory protein 4 (HE4)	AgNPs	Antibody	4 pM	C	Yuan et al., 2012 [56]
Microalbuminuria	AuNPs	Antibody	1000 pg mL^−1	C	Lai et al., 2010 [57]
p53 mutation	AgNPs	Antibody	10 nM	C	Duan et al., 2012 [58]
NADH	AuNPs	Antibody	—	B	Gu et al., 2015 [59]