Nanotechnology-Based Surface Plasmon Resonance Affinity Biosensors for In Vitro Diagnostics

Table 5

Main analytical performances of the reviewed biosensors based on SPR imaging.

Analytes	Nanoparticles	Biotransducer	Detection limit (LOD)	IVDD class	References
Nucleic Acid	AuNPs	Aptamer	1 fM	C	Sendroiu et al., 2011 [60]
miRNA	SiNPs	Aptamer	100 fM	C	Zhou et al., 2011 [61]
miRNA	AuNPs	Aptamer	5 aM	C	Fang et al., 2006 [62]
DNA	AuNPs	Aptamer	10 aM	C	Gifford et al., 2010 [63]
Single nucleotide polymorphisms (SNPs)	AuNPs	Aptamer	1 pM	C	Li et al., 2006 [14, 15]
Single nucleotide polymorphisms (SNPs)	AuNPs	Aptamer	32 nM	C	Sato et al., 2006 [64]
DNA	AuNPs	Aptamer	41 zM	C	D’Agata et al., 2010 [65]
DNA	AuNPs	Aptamer	0.02 aM	C	Yao et al., 2006 [66]
miRNA	AuNPs	Aptamer	—	C	Wood et al., 2013 [67]
IgG	AgNPs	Antibody	1 nM	B	Paul et al., 2011 [68]