Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes

Figure 8

Real-time monitoring by -L¹ on the gefitinib inhibition of P1 phosphorylation by protein tyrosine kinase EGFR. (a) The structure of the inhibitor gefitinib. In (b), gefitinib was added to the solution containing P1, MnCl₂, EGFR kinase, and -L¹, and the reaction was started with addition of ATP. Gray: control without EGFR; red: control without gefitinib. Reproduced with permission from [69]. Copyright 2014, Springer.

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