Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MS/MS Method

Table 5

Pharmacokinetic parameters of BP and BA in rats after intragastric administration.

Parameters	Unit	Values
		BP	BA
	h	1.97 ± 0.23	1.47 ± 0.30
AUC (0–∞)	h ng mL^−1	102.87 ± 31.74	65.81 ± 15.24
MRT (0–∞)	h	2.27 ± 0.32	2.01 ± 0.15
	h	0.35 ± 0.07	0.31 ± 0.03
	h	1.15 ± 0.34	1.74 ± 0.36
	L/h/kg	3.71 ± 0.35	3.79 ± 1.47
	ng/mL	57.23 ± 17.18	49.76 ± 3.51

: half-life for terminal elimination phase; AUC: area under the time-concentration curve; MRT: mean residence time; : time to ; Cl: total plasma clearance; V_d: apparent volume of distribution; : maximum plasma concentration.