Simultaneous Determination of Seven Active Components in Rat Plasma by UHPLC-MS/MS and Application to a Quantitative Study after Oral Administration of Huang-Lian Jie-Du Decoction in High Fat-Induced Atherosclerosis Rats

Table 1

Optimized precursor/production pairs and multiple reaction monitoring (MRM) parameters for the analytes and IS.

Analyte	m/z	DP/V	CE/eV
Baicalin	447.1→271.0	95	30
Baicalein	271.0→123.0	190	44
Wogonoside	461.1→285.0	90	28
Wogonin	285.0→270.0	130	34
Berberine	337.8→294.0	80	38
Palmatine	353.9→322.1	50	54
Jatrorrhizine	339.1→295.0	100	27
Icariin(IS)	677.3→369.1	200	70
Tetrahydropalmatine(IS)	357.2→192.1	210	35