Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies

Figure 2

SRM chromatograms for brigatinib (I), brigatinib-analog (II), and IS in rat plasma: (a) blank rat plasma; (b) blank plasma spiked with the analytes (1.0 ng/mL) and IS; (c) a rat plasma sample collected 1 h after oral administration of 5.0 mg/kg brigatinib; (d) a rat plasma sample collected 1 h after oral administration of 5.0 mg/kg brigatinib-analog.

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