Journals
Publish with us
Publishing partnerships
About us
Blog
International Journal of Analytical Chemistry
Journal overview
For authors
For reviewers
For editors
Table of Contents
Special Issues
International Journal of Analytical Chemistry
/
2020
/
Article
/
Tab 3
/
Research Article
An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib
Table 3
Intraday and interday precision and accuracy of osimertinib in rat plasma.
Analytes
Spiked concentration (ng/mL)
Intraday (
n
= 6)
Interday (
n
= 18)
Mean ± SD (ng/mL)
RSD (%)
Accuracy (%)
Mean ± SD (ng/mL)
RSD (%)
Accuracy (%)
Osimertinib
1 (LLOQ)
1.02 ± 0.11
10.4
102.5
0.99 ± 0.10
10.3
98.5
3 (QC-L)
2.94 ± 0.20
6.9
98.1
2.91 ± 0.20
6.8
97.0
30 (QC-M)
31.0 ± 0.5
1.7
103.2
30.3 ± 1.6
5.2
101.1
350 (QC-H)
368 ± 11
3.1
105.1
365 ± 13
3.5
104.3