Quantitative Analysis of Favipiravir by HPLC: Development and Validation

Table 3

Forced degradation study results under stressful conditions.

Forced degradation of favipiravir
Reagent added/stress condition	Favipiravir		Degradants (%)
	Recovered (%)	Peak purity
0.5 M NaOH & heat in water bath @ 50°C, (15) min	92.6	1000	0.1
0.5 M HCl & heat in water bath @ 70°C, (15) min	88.2	1000	6.11
6% H2O2 & heat in water bath @ 70°C, (15) min	82.9	1000	0.5
Heat in water bath @ 70°C, 15 minutes	94.6	1000	0.1
Under UV light for 24 hours	94.7	1000	0.1