Method Development for Simultaneously Determining Indomethacin and Nicotinamide in New Combination in Oral Dosage Formulations and Co-Amorphous Systems Using Three UV Spectrophotometric Techniques
Table 2
Data of the accuracy tests of IND and NCT for the proposed methods.
Concentration (μg/mL)
IND mean recovery ± RSD %
NCT mean recovery ± RSD %
Method
ZCD2
DWD1
SS
ZCD2
DWD1
RS
5
99.06 ± 0.62
101.71 ± 0.45
99.44 ± 1.78
99.13 ± 1.75
100.15 ± 1.34
99.58 ± 1.41
10
98.79 ± 0.48
100.06 ± 1.44
99.44 ± 0.51
99.92 ± 0.26
99.21 ± 0.75
99.25 ± 1.14
15
99.93 ± 1.75
100.81 ± 1.11
101.59 ± 1.27
99.16 ± 1.53
98.20 ± 0.38
100.46 ± 0.49
20
100.35 ± 0.96
100.22 ± 0.98
100.09 ± 1.01
100.66 ± 0.62
100.46 ± 0.23
100.55 ± 1.52
25
99.78 ± 1.94
100.09 ± 1.66
99.99 ± 0.51
98.48 ± 1.87
100.44 ± 1.30
99.27 ± 0.34
30
99.70 ± 1.88
99.18 ± 0.81
98.98 ± 1.20
100.97 ± 0.55
100.71 ± 0.76
100.13 ± 0.81
Mean recovery ± RSD %
99.60 ± 1.94
100.35 ± 1.25
99.92 ± 1.28
99.72 ± 1.40
99.86 ± 1.17
99.87 ± 1.04
Three repetitions of each concentration were analyzed with nine total repetitions. All 18 repetitions of each wavelength.