Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

<table>Oxidative stress in the cerebral cortex of sedentary male 3xTg-AD mice (TgSED) is partially ameliorated by treadmill running exercise (TgEXE), whereas 3xTg-AD females show less alteration. Tissue of sedentary nontransgenic mice (non-Tg) was analyzed as a reference. (a) Lipid peroxidation levels expressed as malondialdehyde (MDA) plus 4-hydroxyalkenal (4-HAD). (b) Levels of reduced glutathione (GSH). (c) Levels of oxidized glutathione (GSSG). (d) Glutathione peroxidase (GPx) enzymatic activity. (e) SOD-CuZn enzymatic activity. (f) SOD-Mn activity. Data represent the mean ± SEM of 4–8 animals, tested in duplicate. Statistics: <svg height="13.95" id="M380" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.162498 13.95" width="58.162498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to non-Tg; <svg height="15.775" id="M383" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 59.224998 15.775" width="59.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.017,-0,0,-.017,8.737,15.5)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> compared to TgSED.</table>

International Journal of Alzheimer’s Disease

fig4

Figure 4

Figure 4: Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice 