Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner

Table 2

Human proteins with homology to HSV-1 proteins: The size of symbol (HUGO Nomenclature approved gene symbols) is proportional to the number of viral proteins displaying homology to the gene product. Filter “Alzheimer”: all of the genes encoding for these proteins with the exception of those with the strikethrough have been implicated in Alzheimer’s disease in genetic association studies. Filter “cholesterol”: genes encoding for proteins products in dashed boxes have been implicated in Alzheimer’s disease in genetic association studies. No Filter: HSV-1 proteins are most homologous to diverse families of kinases: Those boxed have been shown to phosphorylate the microtubule protein tau (Data from Kinasource and from NCBI Interactions section for the MAPT gene (tau)).

BLAST filter	Gene products with homology to HSV-1 proteins
HSV-1 Filter “Alzheimer”
Hsv-1 Query Cholesterol
HSV-1 No Filter