Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease

Table 1

Significance (𝑃≤.01) of OD values (U Mann and Whitney 𝑡-test) and percentage of AD positive patients on well plates coated with tryptophan-derivative conjugates. OD values for each tryptophan-derivative conjugate were subtracted from those on BSA well plates. Percentages were calculated as follows: number of patients with OD values above mean OD value of controls +2 standard deviations.

		Conjugates coated on well plates
Isotype		Kyn	3-0HKyn	Kyna	Quina	Quinald	3-OHAnthra	Anthra	Xantha
G	Significance	0.0836	0.5746	0.5758	0.8793	0.7513	0.0194	0.1576	0.0635
	Percentage	25.4%	10.9%	10.9%	7.2%	16.3%	9.0%	14.7%	20.0%
M	Significance	0.8275	0.8741	0.9784	0.0000	0.3450	0.2294	0.8172	0.9895
	Percentage	29%	9.0%	18.1%	7.2%	32.7%	14.5%	21.8%	21.8%
A	Significance	0.0015	0.0001	0.0000	0.0027	0.0119	0.0034	0.0026	0.0005
	Percentage	38.1%	58.1%	61.8%	65.4%	43.6%	50.9%	54.5%	63.6%
Isotype		Pico	W	5-HW	5-HT	Mel	5-HIAA	5-HTol	5-MTol
G	Significance	0.0790	0.9042	0.0000	0.0118	0.3873	0.0878	0.4244	0.6936
	Percentage	12.7%	24.1%	27.5%	20.6%	20.6%	10.3%	10.3%	6.8%
M	Significance	0.9737	0.0007	0.0000	0.7928	0.4906	0.4181	0.3696	0.6941
	Percentage	23.6%	3.4%	3.4%	10.3%	10.3%	24.1%	6.8%	3.4%
A	Significance	0.0011	0.0878	0.2836	0.0001	0.0018	0.0001	0.0010	0.0015
	Percentage	65.4%	10.3%	13.7%	62%	51.7%	58.6%	41.3%	51.7%