Staging of Alzheimer's Pathology in Triple Transgenic Mice: A Light and Electron Microscopic Analysis

Figure 2

Schematic drawings representing the distribution of 6E10-ir neurons in 3-week, 2-, and 5-month-old perfusion-fixed 3xTg-AD transgenic mice. Note the age-related increase in the number of 6E10 positive neurons in the cortex, hippocampus, and amygdala. Abbreviations: Aca: anterior commissure, anterior; aci: anterior commissure, intrabulbar, A: amygdala; AO: anterior olfactory nucleus; BLA: basolateral nucleus of the amygdala; CA1: CA1 hippocampal subfield; CA3: CA3 hippocampal subfield; Cg: cingulate cortex; DG: dentate gyrus; Ect: ectorhinal cortex; F: fornix; G: geniculate nucleus; lo: lateral olfactory tract; I: insular cortex, ic: internal capsule; m: motor cortex; m: mammillary complex; ml: medial lemniscus; mt: mammillothalamic tract; opt: optic tract; PAG: periaqueductal gray, Pir: piriform cortex; Pr:L prelimbic cortex; Rn: red nucleus; RS: retrosplenial cortex; S: sensory cortex; SC: superior colliculus; SN: substantia nigra; St: striatum; Su: subiculum; th: thalamus; tu: olfactory tubercle. Small dots = 1–5 positive neurons, medium-size dots = 10–20 positive neurons, and large dots = 100 positive neurons.