Effects of Immunomodulatory Substances on Phagocytosis of A𝛽_{𝟏-𝟒𝟐} by Human Microglia

Figure 1

(a)-(b) Uptake of Aβ _1–42 in human microglial cells. The micrographs in (a) show living human CHME3 microglial cells in culture after incubation with Aβ _1–42, seen by phase contrast and fluorescence microscopy, and after merging of these. The micrographs in (b) show fixed CHME3 microglial cells in suspension after incubation with Aβ _1–42, seen by fluorescence microscopy with filters for propidium iodide (PI) staining and HiLyte488-conjugated Aβ _1–42, respectively, and the micrographs are merged in the 3rd micrograph. Magnifications 10× (a) and 40× (b).

(a)

(b)