CSF Biomarkers Profile in CADASIL—A Model of Pure Vascular Dementia: Usefulness in Differential Diagnosis in the Dementia Disorder

Table 1

Clinical and molecular features of CADASIL patients.

𝑛^∘	CADASIL patients	age	sex	MMSE	mutation	CSF t-tau (pg/ml)	CSF A𝛽1-42 (pg/ml)	CSF p-tau (pg/ml)
1	PV	66	M	24	r207c eter ex4	200	307	40
2	GP	53	F	19	r207c eter ex4	205	193	30
3	MM	50	M	25	r207c eter ex4	174	275	32
4	BAS	52	M	23	r607c eter ex11	295	487	48
5	SS	57	M	15	r607c eter ex11	170	520	32
6	TA	49	M	21	r1076c eter ex20	296	675	45
7	DPM	58	F	29	frame shift aa127–158 stop codon aa159 ex4	438	746	43
8	JF	49	M	24	g528c eter ex11	166	585	29
9	SME	67	M	25	r1076c eter ex20	120	863	27
10	FUS	39	M	23	R332C ex 6	114	244	15
CADASIL patients (10)		54±8,4^a	2F/8M^𝐚	23±3,8^a		187 [155–295]b	504 [267–693]b	32 [28–43]b
Alzheimer patients (22)		66±8,4^a	15F/7M^a	18±4,6^a		1063 [748–1582]b	340 [225–378]b	106 [70–151]b
controls (17)		58±9,9^a	11F/6M^a	30±2,2^a		197 [167–210]b	875 [793–1024]b	32 [26–38]b

MMSE: minimental state examination; avalues are expressed as mean ± S.D.; bvalues are expressed as median [25th–75th percentile].