Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid

Figure 2

Boxplots with whiskers representing minutes and max values. (a) The effect of blood contamination on CSF A𝛽₄₂ levels. The addition of blood to CSF representing an erythrocyte level of 200, 1000 and 5000 /𝜇L of blood did not affect the A𝛽₄₂ level compared with neat CSF. (b) The effect a blood-brain barrier dysfunction on A𝛽₄₂ levels. Plasma was added to CSF at a concentration representing a CSF/serum albumin ratio of 11, 18, 30 and 55. The A𝛽₄₂ concentration was significantly decreased (𝑃<.01) at all added plasma concentrations.

(a)

(b)