Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid

Table 1

Properties of evaluated commercially available A𝛽 assays. The various capture and detection antibodies employed in the different A𝛽₄₂ immunoassays. The differences in antibody epitope recognition and the part of CSF diluted in buffer during the incubation render methodological differences both qualitatively and quantitatively. aa, amino acids.

	Innotest Elisa	Innotest Elisa (4G8)	The genetics	INNO-BIAAlzBio3	INNO-BIAA𝛽 forms	MSD Triplex
Capture (epitope)	21F12; (42 C-terminal)	21F12; (42 C-terminal)	W02; (aa 5–8)	4D7A3; (42 C-terminal)	21F12; (42 C-terminal)	Not declared; (42 C-terminal)
Detection (epitope)	3D6; (aa 1–5)	4G8; (aa 17–24)	G2-13; (42 C-terminal)	3D6; (aa 1–5)	3D6; (aa 1–5)	4G8; (aa 17–24)
CSF; (% v/v)	25	25	50	75	75	50
A𝛽	1–42	x-42	x-42	1–42	1–42	x-42