GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration

<table>Canonical Wnt signaling and GSK3 regulation. Wnt activation through Frizzled receptor (FzR) induces destabilization of the protein complex composed of axin, adenomatous polyposis coli (APC) protein, <i>β</i>-catenin, casein kinase (Ck1), and GSK3, which results in GSK3 inhibition leading to the induction of <i>β</i>-catenin/TCF target gene expression.  When Wnt signalling is off the GSK3/axin complex is not inhibited and <i>β</i>-catenin phosphorylated and is degraded by the proteasome machinery.</table>

International Journal of Alzheimer’s Disease

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Figure 2

Figure 2: GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration 