New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion

Figure 3

Schematic model of the interactions of MT-3 and its implication on the biological functions of MT-3. The hypothetical model describes the process of secretion of MT-3, from the astrocytes into the extracellular milieu, through its interaction with Rab3A, 14-3-3 zeta, Exo84p (Left panel). The uptake of MT-3 into the neurons and their growth regulation: uptake is facilitated through the interaction with the plasminogen (PGn) and enolase (either, αγ or γγ). Once inside the neurons, MT-3 protects the neurons from the extension and the outgrowth through its interaction with DRP-2. In Alzheimer’s disease, oxidative stress alters several proteins involved in the interaction with MT-3, therefore potentially affecting the pathway of secretion and/or the uptake.