Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein
Figure 5
(a) Maturation-dependent increase in AβP-induced [Ca2+]i changes in primary cultured neurons. (b) Heterogeneous affinity of AβP to mature cultured hippocampal neurons. Long-term cultured rat hippocampal neurons were exposed to 1 μM of AβP(1–40) at 29 DIV and fixed after 4 days. Neurons were double immunostained by anti-MAP2 antibody (Texas Red, red) and anti-AβP antibody (FITC, green), and observed by Laser confocal microscopy. Scale bar represents 50 μm. (modified from [100]).
