Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein

Figure 7

Hypothesis concerning amyloid channels and pathogenesis of Alzheimer’s disease. AβPs are secreted from APP in synapses, directly incorporated into membranes. The possible hypothetical scheme of the formation of oligomeric amyloid channels is depicted. Details are shown in the text.