Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice

Table 1

Effect of Centella asiatica (CA; 150 and 300 mg/kg, p.o.) on memory performance in Morris water maze in D-galactose-treated mice.

Treatment (mg/Kg)	Day 20 (IAL)	Day 21 (1st RL)	Day 42 (2nd RL)
Naïve	48.1 ± 2.9	17.3 ± 3.2	12.3 ± 1.4
D-gal (100)	49.8 ± 3.0	58.0 ± 2.2^a	55.1 ± 1.7^a
CA (300)	48.6 ± 2.6	12.5 ± 2.5	9.5 ± 2.4
CA (150) + D-gal (100)	46.5 ± 2.56	43.0 ± 2.7^b	40.6 ± 2.6^b
CA (300) + D-gal (100)	46.3 ± 2.7	28.5 ± 2.5^b,c	25.6 ± 2.4^b,c

The initial acquisition latencies (IAL) on day 20 and retention latencies on days 21 (1st RL) and 42 (2nd RL) following D-gal concurrent treatment were observed. Values are mean ± S.E.M. ^a𝑃<.05 as compared to naive group; ^b𝑃<.05 as compared to D-gal-treated group; ^c𝑃<.05 as compared to CA (150) + D-gal group (repeated measures two-way ANOVA followed by Tukey’s test for multiple comparisons).