MRI Shows More Severe Hippocampal Atrophy and Shape Deformation in Hippocampal Sclerosis Than in Alzheimer's Disease

Table 4

Hippocampal shape deformations expressed as z-scores.

	NC	AD	HS	F(2,40), P
	(𝑛=8)	(𝑛=24)	(𝑛=11)
CA1 Deformation
Left	−0.31 (0.50)	−0.90 (0.59)	−1.54 (1.08)^1	𝐹=6.69, 𝑃=.003
Right	−0.35 (0.44)	−1.07 (0.68)^1	−1.74 (0.85)^1,2	𝐹=9.37, 𝑃=.005
Total	−0.33 (0.42)	−0.99 (0.60)	−1.64 (0.91)^1,2	𝐹=9.02, 𝑃=.006
Subicular Deformation
Left	0.06 (0.19)	−0.39 (0.21)^1	−0.73 (0.41)^1,2	𝐹=19.14, 𝑃<.001
Right	0.09 (0.21)	−0.34 (0.22)^1	−0.67 (0.28)^1,2	𝐹=23.93, 𝑃<.001
Total	0.08 (0.19)	−0.36 (0.20)^1	−0.70 (0.31)^1,2	𝐹=25.71, 𝑃<.001
Combined deformation
Left	0.24 (0.31)	−0.04 (0.33)	0.007 (0.39)	𝐹=2.01, 𝑃=.14
Right	0.08 (0.22)	−0.17 (0.29)	−0.15 (0.33)	𝐹=2.30, 𝑃=.11
Total	0.16 (0.25)	−0.11 (0.27)	−0.07 (0.30)	𝐹=2.88, 𝑃=.07

¹Different from NC, Tukey-Kramer (𝑃<.05).
²Different from AD, Tukey-Kramer (𝑃<.05).