Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis
Figure 2
Zn2+ signaling and glutamate excitotoxicity. Zinc released from zincergic neuron terminals is immediately taken up into presynaptic and postsynaptic neurons through calcium-permeable channels (CaC and GluR). In presynaptic neurons, zinc negatively modulates exocytosis. The negative modulation by zinc may protectively serve for postsynaptic neurons under pathological conditions that are linked with glutamate excitotoxicity.
