Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System

Figure 5

Gamma-secretase-mediated cleavage of viral and pathogen receptors. Gamma secretase substrates are indicated by the square boxes and their pathogen ligands in the oval boxes. Cyto: cytomegalovirus; C. Neo: Cryptococcus neoformans; Adeno: adenovirus; EBV: Epstein-Barr virus; Flu-influenza A.; HepC: hepatitis C; HepE: hepatitis E; HHV-6: human herpesvirus 6; HIV-1: human immunodeficiency virus; HSV-1: herpes simplex; Lassa: Lassa fever virus; LCMV: Lymphocytic choriomeningitis virus; Leprosy: mycobacterium leprae; Meas: measles; Neiss: Neisseria; Papill: papillomavirus; P. Ging: Porphyromonas gingivalis; Pox: Vaccinia and other pox viruses, Rhino: rhinoviruses; Staph: Staphylococcus aureus,Strep: streptococcus; P serine: phosphatidylserine: Alzheimer’s disease susceptibility genes returned from very large genomewide association studies, and APP, are in black, as are the pathogens implicated in Alzheimer’s disease Genes from the pre-GWAS era are in grey.